The main slate features several high-upside, high-strikeout studs, several of whom have favorable matchups. Francisco Liriano might be the sneakiest play of the day, as the Indians rank just 27th in OPS vs. lefties this year.

If you don’t want any of the top five, there are still some interesting choices. Derek Holland has quietly had a nice comeback season and gets a favorable matchup against a Twins team that has struggled vs. southpaws this season. Wade Miley has been a strikeout machine, but no offense has mashed pitchers (especially lefthanded pitchers) like the Nats. Chase Anderson, who’s allowed just one homer all season, is also on the radar despite a tough matchup against the Red Sox.

MORE DFS: Wednesday’s Lineup | Lineup Builder

Daily Fantasy Baseball Rankings: Pitchers

Daily Fantasy Baseball Picks: Wednesday, May 10

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It’s going to be a busy Wednesday with 14 games on the MLB schedule. Of these, five will be of the afternoon variety, and the remaining nine will make up the main DFS slate. While our optimal lineups will be geared for the main slate, we have included a few afternoon plays in the Playbook to get you started on those early contests.

There is some rain expected in Chicago and Denver tonight, and as of now it appears to be pretty significant risk to the Twins-White Sox game. The Cubs-Rockies game has some risk, as well, though with it being a day game, the window to play might be a little bigger. There is also a slight chance of rain in Arlington, but for now it doesn’t look like a big threat.

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Daily Fantasy Baseball Value Picks: Wednesday, May 10

There are a few players that I didn’t do a full write-up on, but like for value plays and may make it into my Optimal Lineups. They include:  

C - Carlos Ruiz (SEA) - FD

C - Jeff Mathis (ARI) - Across the board

1B - Chris Davis (BAL) - FD + Y!

1B - Justin Bour (MIA) - DK + Y!

2B - Yolmer Sanchez (CWS) - DK

2B - Derek Dietrich (MIA) - FD + Y!

2B - Ryan Goins (TOR) - DK + Y!

3B - Joey Gallo (TEX) - DK

3B - Justin Turner (LAD) - DK

3B/SS - Christian Arroyo (SF) - DK + FD

SS - Eduardo Escobar (MIN) - ATB

SS - Erick Aybar (SDP) - ATB

OF - Tommy Pham (STL) - ATB

OF - Magneuris Sierra (STL) - ATB

OF - Kevin Kiermaier (TB) - FD + Y!

OF - Corey Dickerson (TB) - FD + Y!